ANKRD22

Chr 10

ankyrin repeat domain 22

Predicted to act upstream of or within several processes, including calcium ion import; leukocyte migration; and response to wounding. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…
2
Active trials
18
Pubs (1 yr)
P/LP submissions
P/LP missense
1.72
LOEUF
GOF
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint?
1.72LOEUF
pLI 0.000
Z-score -0.36
OE 1.11 (0.721.72)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.21Z-score
OE missense 1.06 (0.911.24)
111 obs / 105.0 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?1.11 (0.721.72)
00.351.4
Missense OE?1.06 (0.911.24)
00.61.4
Synonymous OE?1.07
01.21.6
LoF obs/exp: 13 / 11.7Missense obs/exp: 111 / 105.0Syn Z: -0.37

ClinVar Variant Classifications

0 submitted variants in ClinVar

Protein Context — Lollipop Plot

ANKRD22 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.