ANGPTL3
Chr 1ARangiopoietin like 3
Also known as: ANG-5, ANGPT5, ANL3, FHBL2
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015]
Primary Disease Associations & Inheritance
Clinical highlights
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly tolerant — LoF variants common in population
Tolerant to missense variation
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ANGPTL3 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
A Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of VSA003 in Chinese HoFH Patients
ACTIVE NOT RECRUITINGPhase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
RECRUITINGPhase 2 Dose-Finding Study Evaluating the Efficacy and Safety of EDP167 in Adults With Mixed Dyslipidemia
NOT YET RECRUITINGA Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia
RECRUITINGPhase 1 Clinical Study of MWX203 Injection in Healthy Subjects
ACTIVE NOT RECRUITINGA Dose-exploration Study of EDP167 in HoFH
RECRUITINGA Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)
ACTIVE NOT RECRUITINGA First In Human (FIH) Study to Learn if Different Doses of ALN-ANG3 Are Safe and Well Tolerated in Healthy Adults
ACTIVE NOT RECRUITINGA Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
RECRUITINGAssessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Coronary Plaque Volumes Measured by Coronary Computed Tomography Angiography (CCTA) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)
RECRUITINGPhysiological Effects of ANGPTL3 Variants in Humans
RECRUITINGStudy to Assess the Effects of ALN-ANG3 in Adult Participants With Diabetic Kidney Disease
RECRUITINGExternal Resources
Links to major genomics databases and tools