ANAPC2
Chr 9anaphase promoting complex subunit 2
Also known as: APC2
The ANAPC2 protein is a core component of the anaphase-promoting complex (APC/C), an E3 ubiquitin ligase that controls cell cycle progression by targeting proteins for degradation during mitosis and G1 phase. Mutations cause autosomal dominant intellectual disability with microcephaly and growth retardation, typically presenting in early childhood. This gene is highly constrained against loss-of-function variants, indicating that proper dosage is critical for normal development.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Highly LoF-intolerant (top ~10% of genes)
Moderately missense-constrained (top ~2.5%)
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ANAPC2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools