AMN1

Chr 12

antagonist of mitotic exit network 1 homolog

NCBI Gene: 196394 ENSG00000151743 UniProt: Q8IY45 OMIM: 620564

The AMN1 protein is predicted to function as part of the SCF ubiquitin ligase complex involved in proteasomal protein degradation and is active in microvillus membranes. Currently, no established human diseases have been definitively linked to AMN1 mutations. The gene shows moderate constraint against loss-of-function variants (LOEUF 0.604), suggesting potential clinical significance if pathogenic variants are identified.

OMIM ResearchSummary from RefSeq

Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in microvillus membrane. [provided by Alliance of Genome Resources, Jul 2025]

OMIM ResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant

This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Based on population constraint only.

Active trials

Pubs (1 yr)

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P/LP submissions

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P/LP missense

0.60

LOEUF

Mechanism· predicted