ALDH3A2
Chr 17ARaldehyde dehydrogenase 3 family member A2
Also known as: ALDH10, FALDH, SLS
The protein catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids, functioning in aldehyde detoxification from alcohol metabolism and lipid peroxidation. Mutations cause Sjögren-Larsson syndrome through an autosomal recessive inheritance pattern. The pathogenic mechanism involves loss of function, leading to toxic aldehyde accumulation.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
Predictions shown for reference only — model trained on dominant genes, not applicable to AR conditions.
The Badonyi & Marsh prediction model was trained exclusively on dominant disease genes. Predictions are not reliable for genes with autosomal recessive inheritance and are shown at reduced opacity for reference only.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ALDH3A2 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools