ADM2

Chr 22

adrenomedullin 2

Also known as: AM2, dJ579N16.4

NCBI Gene: 79924ENSG00000128165UniProt: Q7Z4H4

This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]

198
ClinVar variants
0
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— ADM2
📋
ClinVar Variants
198 total variants — no pathogenic classifications of 198 total submissions
Some data sources returned errors (1)

gnomad: Error: gnomAD API error: 502

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

198 submitted variants in ClinVar

ClinVar

Classification Summary

Protein Context — Lollipop Plot

ADM2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
ADRENOMEDULLIN 2; ADM2
MIM #608682 · *
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
Elucidating the causal effects of plasma metabolites on breast cancer from multiple perspectives.
Fang K et al.·Int J Surg
2026
Evidence of Involvement of the Calcitonin Gene-Related Peptide in Restless Legs Syndrome.
Mogavero MP et al.·Mov Disord
2025
Basic and clinical study of the effect of exogenous hyaluronic acid on the quality of acellular dermal matrix combined with thin intermediate split thickness skin graft.
Chen F et al.·Eur J Med Res
2023
Machine learning-based immune prognostic model and ceRNA network construction for lung adenocarcinoma.
He X et al.·J Cancer Res Clin Oncol
2023Functional
Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis.
Wang F et al.·Stem Cell Res Ther
2021
Roles of CLR/RAMP receptor signaling in reproduction and development.
Chang CL et al.·Curr Protein Pept Sci
2013Review
Establishment and characterization of adriamycin-resistant human colorectal adenocarcinoma HCT-15 cell lines with multidrug resistance.
Uchiyama-Kokubu N et al.·Anticancer Drugs
2001
DNA microarray reveals different pathways responding to paclitaxel and docetaxel in non-small cell lung cancer cell line.
Che CL et al.·Int J Clin Exp Pathol
2013
Custom Array Comparative Genomic Hybridization: the Importance of DNA Quality, an Expert Eye, and Variant Validation.
Lantieri F et al.·Int J Mol Sci
2017
Atomic force microscopy in the production of a biovital skin graft based on human acellular dermal matrix produced in-house and in vitro cultured human fibroblasts.
Łabuś W et al.·J Biomed Mater Res B Appl Biomater
2018
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

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External Resources

Links to major genomics databases and tools