ADIRF

Chr 10

adipogenesis regulatory factor

Also known as: AFRO, APM2, C10orf116, apM-2

NCBI Gene: 10974ENSG00000148671UniProt: Q15847

APM2 gene is exclusively expressed in adipose tissue. Its function is currently unknown. [provided by RefSeq, Jul 2008]

ResearchGenerating clinical summary…
0
Active trials
9
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.79
LOEUF
Multiple*
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.79LOEUF
pLI 0.036
Z-score 0.38
OE 0.75 (0.29–1.79)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
-0.05Z-score
OE missense 1.02 (0.79–1.34)
37 obs / 36.2 exp
Tolerant

Tolerant to missense variation

Observed / Expected Ratios?
LoF OE?0.75 (0.29–1.79)
0≤0.351.4
Missense OE?1.02 (0.79–1.34)
0≤0.61.4
Synonymous OE?1.14
0≤1.21.6
LoF obs/exp: 2 / 2.7Missense obs/exp: 37 / 36.2Syn Z: -0.42

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ADIRF · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients