ADGRG3

Chr 16

adhesion G protein-coupled receptor G3

Also known as: GPR97, PB99, PGR26

NCBI Gene: 222487 ENSG00000182885 UniProt: Q86Y34

This gene encodes an adhesion G-protein coupled receptor that binds glucocorticoid hormones like cortisol and regulates B-cell development, inflammation, and innate immunity through G-protein signaling pathways. Mutations cause autosomal recessive polymicrogyria, perisylvian, with seizures and intellectual disability, typically presenting in infancy with developmental delays and epilepsy. The gene shows low constraint against loss-of-function variants, consistent with the recessive inheritance pattern observed in affected patients.

ResearchSummary from RefSeq, UniProt

Enables G protein-coupled receptor activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]

ResearchGenerating clinical summary…

Active trials

Pubs (1 yr)

—

P/LP submissions

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P/LP missense

1.24

LOEUF

Multiple*

Mechanism· predicted

Some data sources returned errors (1)