ADGRF1

Chr 6

adhesion G protein-coupled receptor F1

Also known as: GPR110, KPG_012, PGR19, hGPCR36

NCBI Gene: 266977ENSG00000153292UniProt: Q5T601

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; fat cell differentiation; and nervous system development. Predicted to act upstream of or within memory and positive regulation of CREB transcription factor activity. Predicted to be located in membrane. Predicted to be active in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

153
ClinVar variants
7
Pathogenic / LP
—
pLI score
0
Active trials
Clinical Summary— ADGRF1
📋
ClinVar Variants
7 Pathogenic / Likely Pathogenic· 128 VUS of 153 total submissions
Some data sources returned errors (1)

gnomad: Error: gnomAD API error: 502

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

153 submitted variants in ClinVar

ClinVar

Classification Summary

Pathogenic5
Likely Pathogenic2
VUS128
Likely Benign17
Benign1
5
Pathogenic
2
Likely Pathogenic
128
VUS
17
Likely Benign
1
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
5
0
5
Likely Pathogenic
0
0
2
0
2
VUS
0
128
0
0
128
Likely Benign
0
16
1
0
17
Benign
0
1
0
0
1
Total014580153

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

ADGRF1 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

OMIM — Genotype-Phenotype Relationships

1 OMIM entry

OMIM
Clinical Literature
Landmark / reviewRecent case evidence
Key Publications
Landmark & review papers · by relevance
PubMed
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
Hamann J et al.·Pharmacol Rev
2015Review
A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets in Uterine Corpus Endometrial cancer.
Lei P et al.·Int Immunopharmacol
2022
A novel role of ADGRF1 (GPR110) in promoting cellular quiescence and chemoresistance in human epidermal growth factor receptor 2-positive breast cancer.
Abdulkareem NM et al.·FASEB J
2021
Defining molecular signatures of the solid/pseudopapillary and pseudoglandular patterns in so-called "solid-tubulocystic intrahepatic cholangiocarcinoma vs. NIPBL::NACC1 fusion hepatic carcinoma".
Bajpai P et al.·Pathol Res Pract
2025
The genetic structure of pain in depression patients: A genome-wide association study and proteome-wide association study.
Zhang Z et al.·J Psychiatr Res
2022Cohort
A novel 12-gene signature as independent prognostic model in stage IA and IB lung squamous cell carcinoma patients.
Wang K et al.·Clin Transl Oncol
2021Cohort
Top 10 resultsSearch PubMed ↗
Recent Gene-Specific Literature
Gene in title · MEDLINE · newest first
Europe PMC
Interactions between ADGRF1 (GPR110) and extracellular matrix proteins govern its effects on tumorigenesis in HER2-positive breast cancer.
Abdulkareem NM et al.·Br J Pharmacol
2025
Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1).
Wu M et al.·Elife
2023🔓 Open Access
Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation.
Banerjee S et al.·J Neuroinflammation
2023🔓 Open Access
Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling.
Jones DTD et al.·Nat Commun
2023🔓 Open Access
Interaction between GPR110 (ADGRF1) and tight junction protein occludin implicated in blood-brain barrier permeability.
Huang BX et al.·iScience
2023🔓 Open Access
Top 5 resultsSearch Europe PMC ↗

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools