ADGRA3

Chr 4

adhesion G protein-coupled receptor A3

Also known as: GPR125, PGR21, TEM5L

NCBI Gene: 166647ENSG00000152990UniProt: Q8IWK6OMIM: 612303

This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]

GeneReviewsOMIMResearchGenerating clinical summary…

Clinical highlights

Interpreting a novel variant
This gene is strongly intolerant of loss-of-function variation in the population, so LoF variants warrant close attention. No curated mechanism annotation is available — see the mechanism card for the computational prediction and its caveats.Curated gene-level mechanism — a prior for triage, not a per-variant call.
0
Active trials
5
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
0.36
LOEUF
Multiple*
Mechanism· predicted
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GeneReview available — ADGRA3
Authoritative clinical overview · Recommended first read
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Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Moderate LoF intolerance
LoF Constraint?
0.36LOEUF
pLI 0.293
Z-score 5.57
OE 0.23 (0.15–0.36)
Moderately constrained

More LoF-intolerant than ~75% of genes

Missense Constraint?
0.45Z-score
OE missense 0.95 (0.90–1.01)
694 obs / 728.2 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.23 (0.15–0.36)
0≤0.351.4
Missense OE?0.95 (0.90–1.01)
0≤0.61.4
Synonymous OE?1.05
0≤1.21.6
LoF obs/exp: 14 / 60.9Missense obs/exp: 694 / 728.2Syn Z: -0.71

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ADGRA3 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients