ADAT2

Chr 6

adenosine deaminase tRNA specific 2

Also known as: DEADC1, TAD2, dJ20N2, dJ20N2.1

NCBI Gene: 134637ENSG00000189007UniProt: Q7Z6V5

Predicted to enable tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA wobble adenosine to inosine editing. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

ResearchGenerating clinical summary…
0
Active trials
8
Pubs (1 yr)
—
P/LP submissions
—
P/LP missense
1.57
LOEUF
DN
Mechanism· predicted
Some data sources returned errors (1)

omim: Error: OMIM fetch failed: 429

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

gnomAD
Tolerant — LoF & missense variants common in population
LoF Constraint?
1.57LOEUF
pLI 0.000
Z-score 0.13
OE 0.96 (0.60–1.57)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint?
0.88Z-score
OE missense 0.77 (0.64–0.92)
87 obs / 113.4 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios?
LoF OE?0.96 (0.60–1.57)
0≤0.351.4
Missense OE?0.77 (0.64–0.92)
0≤0.61.4
Synonymous OE?0.94
0≤1.21.6
LoF obs/exp: 11 / 11.5Missense obs/exp: 87 / 113.4Syn Z: 0.29

ClinVar Variant Classifications

0 submitted variants in ClinVar

ClinVar

Protein Context — Lollipop Plot

ADAT2 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

ClinicalTrials.gov

No active trials found for this gene.

Search ClinicalTrials.gov →

External Resources

Links to major genomics databases and tools

Franklin by Genoox
AI-powered variant curation and clinical analysis
DECIPHER
Genomic variants and phenotypes in rare disease patients