ADAM22
Chr 7ARADAM metallopeptidase domain 22
Also known as: ADAM 22, DEE61, EIEE61, MDC2
ADAM22 encodes a non-catalytic metalloprotease-like protein that functions as a neuronal receptor for LGI1 and serves as a probable integrin ligand in the brain, regulating cell adhesion and proliferation. Biallelic mutations cause developmental and epileptic encephalopathy 61 through autosomal recessive inheritance. The gene shows significant constraint against loss-of-function variation (LOEUF 0.363), reflecting its critical role in neuronal function.
Definitive — sufficient evidence for diagnostic panels
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
More LoF-intolerant than ~75% of genes
Moderately missense-constrained (top ~2.5%)
Predictions shown for reference only — model trained on dominant genes, not applicable to AR conditions.
The Badonyi & Marsh prediction model was trained exclusively on dominant disease genes. Predictions are not reliable for genes with autosomal recessive inheritance and are shown at reduced opacity for reference only.
Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ADAM22 · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools