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ADAM15-EFNA4

Chr 1

ADAM15-EFNA4 readthrough

NCBI Gene: 125467744

This locus represents naturally occurring readthrough transcription between the neighboring ADAM15 (ADAM metallopeptidase domain 15) and EFNA4 (ephrin A4) genes on chromosome 1. The readthrough transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Jun 2022]

Research

ResearchGenerating clinical summary…

Clinical Summary— ADAM15-EFNA4

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ClinVar Variants

162 VUS of 261 total submissions

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Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for /lookup/symbol/homo_sapiens/ADAM15-EFNA4?content-type=application/json&expand=1

gnomad: Error: Gene not found

Population Genetics & Constraint

gnomAD

Constraint data not available from gnomAD.

ClinVar Variant Classifications

261 submitted variants in ClinVar

ClinVar

Classification Summary

VUS162

Likely Benign33

Benign3

162

VUS

Likely Benign

Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

Classification	LoF	Missense + Inframe	Non-coding	Synonymous	Total
Pathogenic	0	0	0	0	0
Likely Pathogenic	0	0	0	0	0
VUS	1	161	0	0	162
Likely Benign	0	19	5	9	33
Benign	0	1	2	0	3
Total	1	181	7	9	198

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

4 pathogenic / likely-pathogenic (of 5) ClinVar copy-number / structural variants overlap ADAM15-EFNA4 — these span large chromosomal regions, not the gene specifically, and are excluded from the counts above. Explore in CNV tools →