ACRBP
Chr 12acrosin binding protein
Also known as: CT23, OY-TES-1, SP32
The acrosomal protein binds to and maintains proacrosin as an inactive zymogen in sperm acrosomes and is involved in acrosome formation. This gene is extremely tolerant to loss-of-function variants in the general population, and no Mendelian diseases have been definitively associated with ACRBP mutations in current medical literature.
Population Genetics & Constraint
gnomAD v4 — loss-of-function & missense intolerance
Typical tolerance to LoF variation
Mild missense constraint
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ACRBP · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →External Resources
Links to major genomics databases and tools