ACOT11

Chr 1

acyl-CoA thioesterase 11

Also known as: BFIT, STARD14, THEA, THEM1

The protein is an acyl-CoA thioesterase that converts long-chain fatty acyl-CoA substrates (particularly palmitoyl-CoA and myristoyl-CoA) to free fatty acids and coenzyme A in the mitochondrial beta-oxidation pathway. Mutations cause autosomal recessive defects in fatty acid oxidation, typically presenting in infancy or early childhood with episodes of hypoglycemia, hepatomegaly, and metabolic decompensation during fasting or illness. The gene shows very low constraint against loss-of-function variants (LOEUF 1.08), consistent with recessive inheritance where heterozygous carriers are typically unaffected.

OMIMResearchSummary from RefSeq, UniProt
GOFmechanismLOEUF 1.08
Clinical SummaryACOT11
Population Constraint (gnomAD)
Low constraint (pLI 0.00) — loss-of-function variants are relatively tolerated in the population.
📋
ClinVar Variants
13 unique Pathogenic / Likely Pathogenic· 189 VUS of 263 total submissions

Population Genetics & Constraint

gnomAD v4 — loss-of-function & missense intolerance

Tolerant — LoF & missense variants common in population
LoF Constraint
1.08LOEUF
pLI 0.000
Z-score 1.16
OE 0.79 (0.591.08)
Tolerant

Highly tolerant — LoF variants common in population

Missense Constraint
0.54Z-score
OE missense 0.92 (0.851.01)
363 obs / 393.1 exp
Tolerant

Mild missense constraint

Observed / Expected Ratios
LoF OE0.79 (0.591.08)
00.351.4
Missense OE0.92 (0.851.01)
00.61.4
Synonymous OE0.91
01.21.6
LoF obs/exp: 29 / 36.5Missense obs/exp: 363 / 393.1Syn Z: 0.93
DN
0.5966th %ile
GOF
0.6541th %ile
LOF
0.4726th %ile

The highest-scoring mechanism for this gene is gain-of-function.

GOFprediction above median

Note: In-silico variant effect predictors (SIFT, PolyPhen, REVEL, CADD) may underestimate pathogenicity of missense variants in genes with GOF or DN mechanisms. Consider functional evidence and clinical context.

Predictions from Badonyi M, Marsh JA. PLoS ONE. 2024;19(8):e0307312.

ClinVar Variant Classifications

263 submitted variants in ClinVar

Classification Summary

Pathogenic10
Likely Pathogenic3
VUS189
Likely Benign18
Benign12
10
Pathogenic
3
Likely Pathogenic
189
VUS
18
Likely Benign
12
Benign

Curated Variants Distribution

Classified variants from ClinVar · 5 ACMG categories

ClassificationLoFMissense + InframeNon-codingSynonymousTotal
Pathogenic
0
0
10
0
10
Likely Pathogenic
0
0
3
0
3
VUS
0
183
6
0
189
Likely Benign
2
13
3
0
18
Benign
2
3
3
4
12
Total4199254232

LoF = frameshift, stop gained/lost, canonical splice · Counts from ClinVar esearch · Updated hourly

View in ClinVar →

Protein Context — Lollipop Plot

ACOT11 · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

3D Protein StructureAlphaFold

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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Clinical Literature
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