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ACOGS
Chr 18ADcadherin 2
Also known as: ACOGS, ADHD8, ARVD14, CD325, CDHN, CDw325, NCAD
This protein is a classical cadherin that functions as a calcium-dependent cell adhesion molecule involved in establishing left-right body asymmetry and development of the nervous system, cartilage, and bone. Mutations cause agenesis of corpus callosum, cardiac, ocular, and genital syndrome, which affects multiple organ systems including the brain, heart, eyes, and genitals. The condition follows autosomal dominant inheritance.
Some data sources returned errors (2)
ensembl: Error: Ensembl fetch failed: 400 for https://rest.ensembl.org/lookup/symbol/homo_sapiens/ACOGS?content-type=application/json&expand=1
gnomad: Error: Gene not found
Population Genetics & Constraint
Constraint data not available from gnomAD.
ClinVar Variant Classifications
0 submitted variants in ClinVar
Protein Context — Lollipop Plot
ACOGS · protein map & ClinVar variants
Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.
3D Protein StructureAlphaFold
External Resources
Links to major genomics databases and tools
Clinical Trials
Active and recruiting trials from ClinicalTrials.gov
No active trials found for this gene.
Search ClinicalTrials.gov →No open access results found
External Resources
Links to major genomics databases and tools