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ACCIID

Chr 4AD

protein phosphatase 3 catalytic subunit alpha

Also known as: ACCIID, CALN, CALNA, CALNA1, CNA1, DEE91, IECEE, IECEE1

Enables several functions, including ATPase binding activity; calmodulin binding activity; and calmodulin-dependent protein phosphatase activity. Involved in several processes, including calcineurin-NFAT signaling cascade; negative regulation of angiotensin-activated signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in cytoplasmic side of plasma membrane; cytosol; and dendritic spine. Part of calcineurin complex. Implicated in developmental and epileptic encephalopathy 91. Biomarker of cholangiocarcinoma; focal segmental glomerulosclerosis; and schizophrenia. [provided by Alliance of Genome Resources, Jun 2026]

OMIMResearchGenerating clinical summary…

Primary Disease Associations & Inheritance

Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual developmentMIM #618265
AD

Clinical highlights

Gene–disease validity
Not independently assessedOMIM lists Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development; no ClinGen or GenCC tier
0
Active trials
0
Pubs (1 yr)
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P/LP submissions
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P/LP missense
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LOEUF
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Mechanism
Some data sources returned errors (2)

ensembl: Error: Ensembl fetch failed: 400 for /lookup/symbol/homo_sapiens/ACCIID?content-type=application/json

gnomad: Error: Gene not found

Population Genetics & Constraint

Constraint data not available from gnomAD.

ClinVar

No ClinVar data available.

Protein Context — Lollipop Plot

ACCIID · protein map & ClinVar variants

Showing all ClinVar variants across the protein. Search a specific variant to highlight its position.

Clinical Trials

Active and recruiting trials from ClinicalTrials.gov

No active trials found for this gene.

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